Research Studies

Tear Proteomics in Keratoconus

Originally published in Contact Lens Today.


The purpose of this work was to identify potential tear-film based proteins expressed in keratoconus.

Recruited subjects were normal GP contact lens wearers, keratoconus subjects wearing GP contact lenses, and keratoconus subjects without contact lenses. Subjects wearing soft lenses or having previous ocular surgeries were excluded from participating. Approximately 5 microliters of tears were sampled from both eyes of each subject using glass microcapillaries.

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Research Study – A Comparison of SynergEyes KC Lens versus Traditional RGP Lens Designs for Patients with Irregular Cornea


Objectives. To compare whether patients with irregular corneas are more comfortable wearing SynergEyes®, a hybrid contact lens, compared with rigid gas permeable contact lenses.

Methods. A retrospective chart review of patients seen from the specialty contact lens practice at the University of Pittsburgh, who were refit with hybrid lenses from November 2005 to December 2006. Inclusion criteria included presence of irregular astigmatism in at least one eye from any cause,

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Clinical Research Study – SynergEyes KC Lenses

Purpose: To discuss the initial results of fitting SynergEyes hybrid contact lenses (SynergEyes, Inc, Carlsbad, CA) for keratoconus (KC) and pellucid marginal degeneration (PMD).

Methods: The charts of patients fit with SynergEyes lenses during the first 7 months the lens was available on the Cornea Service at Wills Eye Institute (August 3, 2006 to March 5, 2007) were retrospectively reviewed.

Results: Sixty-one eyes (44 patients) with KC (58 eyes) or PMD (3 eyes) were fit with SynergEyes hybrid contacts.

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